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PREVENTING
ASTHMA-RELATED
ED READMISSIONS
EDMONTON, ALBERTAContinued use of inhaled corticosteroids initially given during emergency department (ED) visits for acute asthma may significantly decrease the number of subsequent visits, two new studies confirm.[1,2]
Asthma accounts for almost two million ED visits annually. About 30% of asthma patients treated in the ED will have a relapse in symptoms. Don D. Sin, MD, MPH, Assistant Professor of Medicine at the University of Alberta, noted that once a relapse occurs, the risk of asthma-related morbidity and mortality rises sharply.
Asthma is an episodic disease with frequent flare-ups in some individuals, observed Dr. Sin. So, relapses [can be] expected in patients with moderate to severe disease.
STEROIDS VERSUS NO STEROIDS
Dr. Sin and his colleague S. F. Paul Man, MD, analyzed ED discharge data from 1,293 patients ranging in age from 5 to 60 years who were admitted to the ED because of asthma-related symptoms between April 1, 1997, and March 31, 2001. The use of all asthma medications was recorded for each patient.[1]
During the four-year study, 658 patients received no inhaled corticosteroids. Of the 459 patients who were given inhaled corticosteroids, 241 received low-dose, 96 received medium-dose, and 122 received high-dose therapy.
Four hundred sixty-two patients had subsequent ED visits for asthma. Patients who used inhaled corticosteroids following initial ED discharge had a 45% lower risk of a subsequent ED visit than did nonusers. Low-dose corticosteroid therapy was as effective as higher doses in reducing the risk of a subsequent ED visit.
The effectiveness of inhaled corticosteroids was independent of the other medications administered. For example, inhaled corticosteroids markedly lowered the risk of a subsequent ED visit in patients who had received at least one dose from a bronchodilator. A similar pattern was observed in patients given oral corticosteroids.
In an
interview with PULMONARY REVIEWS,
Dr. Sin said that the beneficial effect of inhaled corticosteroids
on relapse rates was expected. However, he added, What
was surprising was that more than 50% of patients did
not receive inhaled corticosteroids during the [study] period,
despite being in an emergency department.
INHALED OR SYSTEMIC CORTICOSTEROIDS?
Marcia
Edmonds, MD, MSc, and colleagues conducted a meta-analysis
that included data from six placebo-controlled trials that
studied patients treated in the ED for acute asthma.[2]
Two of the six trials evaluated treatment with inhaled plus systemic corticosteroids versus systemic corticosteroids plus placebo. The other four trials studied inhaled corticosteroids versus placebo.
The most beneficial effect on pulmonary function was found in the groups who received either the highest (18 mg of flunisolide) or the lowest (200 µg of beclomethasone) doses of inhaled corticosteroids. However, because of the small number of studies available for analysis, not enough data existed to allow the authors to form a conclusion about the beneficial effects of inhaled corticosteroids on pulmonary function.
In the studies in which inhaled and systemic corticosteroids were compared with systemic corticosteroids alone, the addition of inhaled therapy appeared to lower hospital admission rates, but the results did not reach significance. When results from all six studies were pooled, however, they showed a 55% reduction in hospital readmission after the use of inhaled corticosteroids following the initial visit to the ED.
LOW DOSES ARE AS EFFECTIVE AS HIGHER ONES
The findings of Drs. Sin and Man concur with those of Dr. Edmonds and colleagues. Drs. Sin and Man commented that some physicians believe more is better when it comes to the use of inhaled corticosteroids in asthma. However, both studies detected evidence suggesting that low doses are effective in reducing relapse rates leading to ED readmission.
Both studies found that inhaled corticosteroids introduced in the ED resulted in a decrease in hospital admission for acute asthma exacerbations. According to Dr. Sin, Some physicians still are not prescribing [inhaled corticosteroids] despite the overwhelming evidence that these medications reduce morbidity in asthma.
PATIENT EDUCATION NECESSARY
Even if an inhaled corticosteroid is prescribed, however, patients may not fill their prescriptions. They may feel that these medications are not particularly helpful, they may be fearful of the side effects of steroids, or the medications may be too expensive, said Dr. Sin.
With education and reinforcement, many patient concerns can be addressed and overcome, but Dr. Sin noted that this is easier said than done. In a busy primary care practice, the educational component of therapy is usually missing. Patients generally receive a prescription and nothing else. There is a missed opportunity in the ED for getting patients started on inhaled corticosteroid therapy.
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A
PARENTS-EYE VIEW OF FOLLOW-UP CARE
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ST.
LOUISA
recent study suggests that low-income urban parents
would seek follow-up care for their asthmatic children
after an emergency department (ED) visit if that care
were easier to obtain.[1] Previous research has shown
that although more than 90% of urban children
have a source of primary medical care, approximately
75% of their families do not use it for asthma
management. Instead, children are brought to the ED
for care.
Sharon
Smith, MD, Assistant Professor of Pediatrics at Washington
University School of Medicine, St. Louis, told PULMONARY REVIEWS, Most parents in our community view
asthma as an episodic illness. They are aware that
their child has asthma, but treatment is sought only
when their child is symptomatic.
Dr.
Smith and colleagues created a questionnaire that
covered parental perceptions of the pros and cons
of follow-up care. It contained 41 statements considered
to be reasons for or against seeking follow-up asthma
care. One hundred forty-seven parents were asked to
rate the statements on a scale of 1 to 5 (5 =
extremely important and 1 = not
important).
Statements
were grouped into four categories: information pro,
attitudinal pro, information con, and attitudinal
con.
OBSTACLES
TO SEEKING CARE
Results
showed that barriers to care occur on many levelsboth
practical and ideological. For example, one parent
may be influenced by his or her negative beliefs about
the need for asthma care, whereas another may be influenced
by logistical problems, such as finding transportation
or a baby-sitter. Both of these cons, though unrelated,
have the same negative effect on follow-up behavior.
Dr.
Smith, who is also an emergency physician at St. Louis
Childrens Hospital, noted that most primary
care physicians are aware that parents have barriers
to care. She adds, however, I am not sure if
they fully appreciate how this impacts a familys
ability or desire to seek follow-up or regular asthma
care.
Although
the con items on this questionnaire were not given
high ratings, the observed low level of follow-up
care among this group suggests that parents do not
know or appreciate the benefits of follow-up care.
However, the high ratings given to the pro items suggest
that parents believe that follow-up care can help
their child.
WHATS
A DOCTOR TO DO?
I
think the most important thing a primary care provider
can do to improve follow-up visits is to educate the
office staff about the importance of and need for
follow-up care, Dr. Smith remarked. Many
parents in our study reported that it was difficult
to make an appointment on short notice, and some office
staff told parents that if their child had no symptoms,
they did not need to be seen.
According
to Dr. Smith, most ED physicians will treat a childs
acute symptoms and send the child home with appropriate
instructions and medication for the next few days.
This does not address long-term management, however.
How do parents treat the childs asthma
after the ED visit? she asked. Well, in
our experience, most parents go back to treating the
child as they did before the ED visit.
Dr.
Smith noted that if a child gets sick enough to require
an ED visit, then there is a problem with that childs
home management plan or action plan. A follow-up
visit provides an opportunity to review the childs
medications and action plan as well as help educate
the parents about early recognition of an impending
exacerbation. This would help prevent another ED visit.
Gale
Jurasek
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Reference
1. Smith SR, Highstein GR, Jaffe DM, et al. Parental
impressions of the benefits (pros) and barriers (cons)
of follow-up care after an acute emergency department
visit for children with asthma. Pediatrics.
2002;110:323-330.
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Gale
Jurasek
References
1. Sin DD, Man SFP. Low-dose inhaled corticosteroid therapy
and risk of emergency department visits for asthma. Arch
Intern Med. 2002;162:1591-1595.
2. Edmonds ML, Camargo CA Jr, Pollack CV Jr, Rowe BH. The
effectiveness of inhaled corticosteroids in the emergency
department treatment of acute asthma: a meta-analysis. Ann
Emerg Med. 2002;40:145-154.
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